Febactum™ (Cefoperazone + Sulbactam Injection)

Product Description
Febactum™ is a combined antibiotic injection comprising Cefoperazone sodium and Sulbactam sodium. Cefoperazone, a third-generation cephalosporin antibiotic, works by disrupting the formation of bacterial cell walls, leading to bacterial lysis and death. Sulbactam acts as a beta-lactamase inhibitor, preventing bacteria from destroying Cefoperazone, thus enhancing the effectiveness of the antibiotic therapy. This potent dual-action formulation targets a broad spectrum of Gram-positive and Gram-negative bacteria, including multi-drug resistant strains, making Febactum™ invaluable in managing severe and complicated bacterial infections.

Indications
Febactum™ is used in the treatment of a variety of systemic infections such as:

• Respiratory tract infections (pneumonia, bronchitis)

• Urinary tract infections

• Skin and soft tissue infections

• Bone and joint infections

• Intra-abdominal infections

• Septicemia

Scientific and Clinical Data

• Pharmacodynamics: Cefoperazone inhibits bacterial cell wall synthesis. Sulbactam extends the antibacterial spectrum by inhibiting beta-lactamase enzymes.

• Pharmacokinetics: Exhibits rapid systemic absorption and distribution, with elimination primarily via the biliary system.

• Clinical trials have demonstrated enhanced cure rates and infection control in patients treated with Cefoperazone/Sulbactam combination compared to Cefoperazone alone.

• Spectrum of Activity: Active against Streptococcus, Staphylococcus aureus (methicillin-sensitive), Enterobacteriaceae, Pseudomonas aeruginosa, and anaerobes.

Dosage and Administration
Febactum™ should only be administered by healthcare professionals. The dosage regimen depends on infection type and severity, typically 1-2 grams administered intravenously or intramuscularly every 12 hours. Dosage adjustments are recommended for patients with renal or hepatic impairment. The full prescribed course should be completed to prevent resistance development.

Safety Profile and Precautions
Febactum™ is generally well tolerated. Possible adverse effects include allergic reactions, injection site pain, gastrointestinal disturbances, and transient changes in liver function tests. Use with caution in patients with known hypersensitivity to beta-lactam antibiotics. Not recommended during pregnancy or lactation unless clearly needed.

Storage and Handling
Store in a cool, dry place below 25°C. Protect from light. Use sterile techniques during preparation and administration.