Levostra®-500MG | Levofloxacin Tablets IP 500 mg

Authoritative product information and pharmaceutical validation from FENESTRA PHARMACEUTICALS.

Levostra®-500MG Tablet Official Product, Levostra® Product Details.

Comprehensive Levostra®-500MG Overview

Levostra®-500MG is an advanced third-generation fluoroquinolone antibiotic formulated for the treatment of severe, complicated, and uncomplicated bacterial infections of the respiratory tract, urinary tract, skin, and soft tissues. Each film-coated tablet delivers:

• Levofloxacin Hemihydrate (IP): eq. to Levofloxacin 500 mg

• Excipients: q.s.

• Colour: Titanium Dioxide IP

Marketed by FENESTRA PHARMACEUTICALS PVT. LTD. (An ISO 9001:2015 Certified Company) and manufactured by Casca Remedies Pvt. Ltd. (A WHO-GMP & GLP Certified Company) in compliance with pharmaceutical safety and statutory pharmacopoeial standards.

Key Features & Health Benefits

• High Clinical Success Rate: Demonstrates superior clinical and microbiological clearance in lower respiratory tract infections, community-acquired pneumonia (CAP), and acute bacterial exacerbation of chronic bronchitis (ABECB).

• Deep Tissue Penetration: Reaches therapeutic concentrations in pulmonary tissues, bronchial mucosa, epithelial lining fluid, sinus tissues, and urine that exceed the Minimum Inhibitory Concentration (MIC) for most susceptible isolates.

• Convenient Once-Daily Dosing: The sustained plasma half-life of 6 to 8 hours allows once-daily therapeutic coverage, minimizing missed doses and reducing the emergence of antimicrobial resistance.

• Clinically Indicated for: Community-acquired pneumonia (CAP), acute bacterial sinusitis, complicated and uncomplicated urinary tract infections (UTIs), acute pyelonephritis, chronic bacterial prostatitis, and skin and soft tissue infections (SSTIs).

Scientific Clinical Citations

• Clinical Efficacy in Respiratory Infections: Multicenter comparative trials highlight Levofloxacin 500 mg once-daily achieves clinical cure rates exceeding 90% in community-acquired pneumonia, with notable activity against Streptococcus pneumoniae (including multidrug-resistant strains).

• Pharmacokinetics & Bioequivalence: Extensive clinical pharmacology data confirm near-complete oral absorption (~99%) unaffected by standard meal timings, matching the pharmacokinetic AUC of IV formulations.

• Urinary Clearance & Urology Guidelines: Documented extensive renal excretion as an unchanged drug provides potent bactericidal concentrations in urine, rendering it highly effective against E. coli, Klebsiella pneumoniae, and Proteus mirabilis.

Directions for Use

• Dosage: As directed by the Physician. Swallow whole with a glass of water; do not crush or chew.

• Storage: Store in a cool, dark & dry place, below 25°C. Protect from light & moisture.

• Packaging Presentation: 10 × 10 Tablets (10 tablets per strip).

• Precaution / Warning:

  • SCHEDULE H1 DRUG PRESCRIPTION CAUTION: It is dangerous to take this preparation except in accordance with the medical advice. Not to be sold by retail without the prescription of a Registered Medical Practitioner.

  • Special Warning: This drug may cause low blood sugar and mental health-related side effects.

  • Keep the medicine out of reach of children.

FAQs – Frequently Asked Questions

What is Levostra®-500MG prescribed for?

Levostra®-500MG is indicated for bacterial infections including pneumonia, acute exacerbations of chronic bronchitis, acute sinusitis, complicated urinary tract infections, kidney infections (pyelonephritis), and bacterial skin infections.

How does Levostra®-500MG work?

It belongs to the fluoroquinolone class of antibiotics. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes required for bacterial cell growth and division, leading to rapid bacterial cell death.

Is Levostra®-500MG available over-the-counter?

No. Levostra®-500MG is a Schedule H1 prescription medicine and can only be purchased with a valid prescription from a registered medical practitioner.

Can Levostra®-500MG be taken with antacids or mineral supplements?

Antacids containing magnesium or aluminum, as well as iron or zinc supplements, can significantly bind to levofloxacin and decrease its absorption. They should be taken at least 2 hours before or 2 hours after taking Levostra®-500MG.

How should Levostra®-500MG be stored?

Store below 25°C in a cool, dry, and dark environment. Keep the strips protected from humidity and direct sunlight.

Regulatory Compliance & Trust

• Manufactured in WHO-GMP & GLP Certified facilities ensuring world-class pharmaceutical production and validation.

• Tested and labeled in strict adherence to the Indian Pharmacopoeia (IP) and Schedule H1 statutory guidelines.

• Every batch undergoes verified chromatographic assay analysis, dissolution testing, and stringent traceability protocols.

• Marketed by Fenestra Pharmaceuticals Pvt. Ltd., Bangalore – ensuring high-standard therapeutic formulations and ethical medical distribution.